Active Ingredient: Methyl Isothiocyanate (MITC), Metam-Sodium, Potassium N-Methyldithiocarbamate (Metam Potassium), and Dazomet
Human Health Risk Assessment and Mitigation
Documents and Activities

Back to Human Health Risk Assessment and Mitigation


Methyl Isothiocyanate (MITC), a volatile soil fumigant with broad, non-selective biocidal activity, results from the breakdown of metam-sodium, potassium N-methyldithiocarbamate (metam potassium), and dazomet when applied to warm, moist soil.


Overview

Methyl isothiocyanate (MITC)
392
Organosulfur
Bactericide, Fungicide
Yes
Yes, with exceptions
Yes
Yes
No
Not applicable

 

Metam-sodium
616
Organosulfur
Antimicrobial, Fungicide, Herbicide, Insecticide,
Nematicide
Yes
Yes, with exceptions
Yes
Yes
No
Concluded

 

Potassium N-methyldithiocarbamate
(metam potassium)
970
Organosulfur
Algaecide, Antimicrobial, Bactericide, Disinfectant, Fungicide, Herbicide, Insecticide, Nematicide,
Slimicide
Yes
Yes, with exceptions
Yes
Yes
No
Concluded

 

Dazomet
233
Organosulfur
Algaecide, Antimicrobial, Bactericide, Disinfectant, Fungicide, Herbicide, Insecticide, Nematicide,
Slimicide
Yes
Yes
Yes
Yes
Yes
Concluded

 

Risk Assessment Documents

Risk Characterization Documents (RCDs) estimate the nature and likelihood of adverse health effects in humans who may be exposed to pesticides.

Other Documents

  • June 2017 Methyl Isothiocyanate (MITC) — Calculation of Intermediate (1-month) and Annual Residential Exposures and Risk Using Measured Air Concentrations from the Ambient Air Monitoring Network (PDF)
  • July 2010 WHS Branch Involvement Related to the Investigation of Priority Illness Episode 26-Ker-05 (Project 0508) (PDF)
  • April 2010 A Worker Health and Safety Investigation of Fieldworker Exposure To Methylisothiocyanate After a Metam Sodium Application; Priority Illness 60-Mon-08 (Project 0802) (PDF)
  • August 2008 Calculation of Eight-Hour Maximum Methyl Isothiocyanate Flux from Dazomet Applications (PDF)
  • August 2008 Environmental Monitoring Results of Multi-Fumigant Applications in Manteca, California 2005
  • July 2008 Environmental Monitoring Results of Basamid®G (Dazomet) Application in Watsonville, California 2006
  • September 2007 An Evaluation Of Illnesses Associated With Exposure To Agricultural Uses Of Metam Sodium, Metam Potassium, And Dazomet (PDF)
  • April 2006 Dazomet Flux Analysis and Recommendations for Future Study (PDF)
  • November 2005 Estimation of Methyl Isothiocyanate Air Concentrations Associated with Priority Case Number 026-KER-05 (PDF)
  • October 2005 Flux Estimation Calculated from a Sprinkler Application of Methyl Isothiocyanate
  • July 2005 Illnesses Related to Shank Application of Metam-Sodium, Arvin, California, July 2002 (PDF)
  • June 2005 Monitoring a 1,3-Dichloropropene/Metam Sodium Application in Del Norte County
    • Appendices
    • Laboratory Method
  • March 2005 Monitoring an Untarped Bedded Drip Application of Metam Sodium in Merced County-Spring 2004
    • Attachments
  • February 2005 Variability in Daytime Stability Class Designation under Partly Foggy Conditions in a Monitoring Study (PDF)
  • December 2004 Determination of MITC Soil Flux Density and Emission Ratio from a Field Following a Tarped Bed Drip Application of Metam-Sodium
  • June 2004 Estimation of Exposure of Persons in California to Metam-Sodium during Soil Applications of Products Containing Metam-Sodium (PDF)
  • June 2004 Final Report for the 2002 Application Air Monitoring for Metam Sodium Breakdown Products in Ventura County
    • Appendices
  • January 2004 Final Report for the 2001 Ambient Air Monitoring for Chloropicrin and Metam Sodium Breakdown Products in Monterey and Santa Cruz Counties
    • Appendices
  • November 2003 Final Report for the 2001 Ambient Air Monitoring for Chloropicrin and Metam Sodium Breakdown Products in Kern County
    • Appendices
  • August 2002 Statistical Confidence that the Maximum 24-Hour MITC Concentration Was Captured in the 2000 Lompoc Fumigant Monitoring (PDF)
  • January 2002 Response to Comments on Metam-Sodium Exposure Assessment Document (HS-1703) (PDF)
  • August 2001 Illness Related to Exposure to Metam-Sodium Byproducts in Earlimart, California in November 1999 (PDF)
  • November 2000 Metam Sodium: In Vitro Absorption Through Rat and Human Skin (PDF)
  • November 1999 Revised Evaluation of Potential Chronic and Subchronic Exposure to Methyl Isothiocyanate Using Pesticide Use Report Data (PDF)
  • June 1998 Dermal Absorption of Tralomethrin, Metam-Sodium, Tribufos, Azinphos-Methyl, and Amitraz in Rats (PDF)
  • June 1997 Ambient Air Monitoring for MIC and MITC After Soil Injection Application of Metam Sodium in Kern County during August 1995
    • Appendices
  • June 1994 Air Monitoring for Methyl Isothiocyanate during a Sprinkler Application of Metam-Sodium
    • Executive Summary
  • May 1994 Metam Sodium - Methods of Application and Annual Number of Occupational Exposure Days (PDF)
  • April 1994 Ambient Air Monitoring for MITC in Kern County During Summer 1993 After a Ground Injection Application of Metam Sodium to a Field
    • Appendices
  • April 1994 Ambient Air Monitoring for MITC in Kern County During Summer 1993
    • Appendices
  • November 1993 Comments on the Use of Vaporooter and "Generic" Use of Metam Sodium for Treating Sewer Systems (PDF)
  • July 1993 Ambient Air Monitoring in Contra Costa County During March 1993 After an Application of Metam Sodium to a Field
    • Appendices
  • July 1993 Metam Sodium: In vivo Dermal Absorption in the Rat and Stability Determination of Aqueous Solutions (PDF)
  • October 1991 Monitoring of the Cantara Metam-Sodium Spill (PDF)
Risk Management Directives (RMDs)

RMDs identify pesticide exposures that require mitigation in order to further protect human health.

Mitigation Documents

Enforcement Letters

Outreach Activities and Materials
  • May 2010 Pesticide Registration and Evaluation Committee Meeting Agenda (PDF)
    • Proposed Mitigation Measures for MITC Generating Pesticides (PDF)
    • Pesticide Registration and Evaluation Committee Meeting Minutes (PDF)
  • November 2009 Agricultural Pest Control Advisory Committee Meeting Agenda (PDF)
    • Agricultural Pest Control Advisory Committee Meeting Minutes (PDF)
  • November 2008 Agricultural Pest Control Advisory Committee Meeting Agenda (PDF)
  • April 2007 Agricultural Pest Control Advisory Committee Meeting Agenda (PDF)
    • Agricultural Pest Control Advisory Committee Meeting Minutes (PDF)
  • 2004 Modeling of Methyl Isothiocyanate Air Concentrations Associated with Community Illnesses Following a Metam-Sodium Sprinkler Application
  • 2003 Illnesses Associated with a November 1999 Sprinkler Application of Metam Sodium in Earlimart, CA (PDF)
  • 2003 Methyl Isothiocyanate (MITC): Risk to Humans Following Agricultural Applications of Metam Sodium (PDF)

For content questions, contact:

Ann Schaffner
Worker Health and Safety Branch
1001 I Street, P.O. Box 4015
Sacramento, CA 95812-4015
Phone: (916) 445-4222
E-mail: Ann.Schaffner@cdpr.ca.gov

Kara James
Pesticide Registration Branch
1001 I Street, P.O. Box 4015
Sacramento, CA 95812-4015
Phone: (916) 324-3523
E-mail: Kara.James@cdpr.ca.gov