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Methyl Iodide - Risk Characterization Process

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State law (Food and Agricultural Code, FAC, sections 13121-13130) requires DPR to review the toxicology database of all pesticide active ingredients. In addition, FAC section 12824 requires DPR to do a thorough evaluation of a new active ingredient before registration. After a preliminary review of toxicology studies, DPR identified methyl iodide (iodomethane) as having potential adverse health effects which a more in-depth appraisal of risk could examine before a registration decision was made. During the risk characterization process, DPR evaluates the significance of the adverse effects. If DPR decides that use of a pesticide results in a significant adverse effect, action must be taken to mitigate the adverse effect. This may include use restrictions or denial of registration.

• Notice of Initiation of Risk Assessment Process for the New Active Ingredient Iodomethane (PDF, 119 kb) (August 2004)
• Risk characterization document (final- February 2010)
  • Volume 1 (PDF, 886 kb) - Health Risk Assessment
    • Appendices (PDF, 835 kb) (Appendix A: Review of Physiologically Based Pharmacokinetic Model for Human-Equivalent Concentration; Appendix B: Calculations; Appendix C: U.S. Environmental Protection Agency Risk Assessment)
  • Volume II (PDF, 1.1 mb) – Exposure Assessment
  • Volume III (PDF, 274 kb) – Environmental Fate
  • Volume IV – Responses to comments (on August 2009 draft)
    • Responses to external peer review panel (PDF, 1.4 mb)
    • Responses to public comments (PDF, 4 mb)
• Draft risk characterization document (August 2009)
  • Volume 1 (PDF, 886 kb) - Health Risk Assessment
    • Appendices (PDF, 835 kb) (Appendix A: Review of Physiologically Based Pharmacokinetic Model for Human-Equivalent Concentration; Appendix B: Calculations; Appendix C: U.S. Environmental Protection Agency Risk Assessment)
  • Volume II (PDF, 1.1 mb) – Exposure Assessment
  • Volume III (PDF, 274 kb) – Environmental Fate
  • Volume IV – Responses to comments (on April 2009 draft)
    • Responses to OEHHA (PDF, 1.4 mb)
    • Responses to U.S. EPA, Part A (PDF, 11.3 mb)
    • Responses to U.S. EPA, Part B (PDF, 890 kb)
    • Responses to Arysta LifeScience Corp. (PDF, 975 kb)
• External peer review and public comment
  Following standard procedure, DPR’s draft risk assessment was peer-reviewed by Cal/EPA's Office of Environmental Health Hazard Assessment and the U.S. Environmental Protection Agency. DPR also posted its draft risk assessment online for written public comment and contracted for an additional external peer review by a panel of scientific experts. The panel held a two-day public workshop in September 2009.
  
  • Workshop presentations
    • Human Health Risk Assessment (PDF. 534 kb) - DPR Medical Toxicology Branch
    • Estimation of Exposures from Pesticide Products Containing Methyl Iodide (PDF, 486 kb) - DPR Worker Health and Safety Branch and Environmental Monitoring Branch
    • Methyl Iodide Water Evaluation (PDF, 21 kb) - DPR Environmental Monitoring Branch
    • Review of DPR’s Draft Methyl Iodide Risk Assessment (PDF, 102 kb) - Office of Environmental Health Hazard Assessment
    • Iodomethane Risk Assessment Overview (PDF, 321 kb) - U.S. Environmental Protection Agency
    • Arysta LifeScience Corp. presentation (PDF, 840 kb)
    • Review of Exposure Assessment (PDF, 278 kb) - California Rural Legal Assistance Foundation
    • Risk Characterization Review (PDF, 993 kb) - Pesticide Action Network
  • Transcripts of workshop (uncorrected)
    • September 24, 2009 (PDF, 400 kb)
    • September 25, 2009 (PDF, 417 kb)
  • Written comments received on draft RCD
  • External peer review panel's report to DPR (PDF, 27 kb) (February 2010); Appendix 1 (PDF, 786 kb); Appendix 2 (PDF, 516 kb); Appendix 3 (PDF, 80 kb)
• U.S. EPA documents
  • Iodomethane Fact Sheet (PDF, 211 kb)
  • Revised Human Health Risk Assessment (August 2007) (PDF, 6.4 mb)
  • Extension of Conditional Registration